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30970

Sodium deoxycholate

Name: Sodium deoxycholate
Brand: SIGMA

BioXtra, ≥98.0% (dry matter, NT)

동의어(들):

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₄H₃₉NaO₄

CAS 번호:

302-95-4

Molecular Weight:

414.55

UNSPSC Code:

12161900

NACRES:

NA.21

PubChem Substance ID:

57648497

EC Number:

206-132-7

Beilstein/REAXYS Number:

3581950

MDL number:

MFCD00064139

기술 서비스

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도움 문의

속성

biological source

ox bile

Quality Level

300

description

anionic

product line

BioXtra

assay

≥98.0% (dry matter, NT)

form

powder

optical activity

[α]20/D +44±2°, c = 2% in H₂O

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

impurities

≤1% cholic acid (HPLC), ≤6% water

CMC

2-6 mM (20-25°C)

solubility

water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow

cation traces

Ca: ≤500 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤10 mg/kg, Mg: ≤10 mg/kg, Mn: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤10 mg/kg, Zn: ≤5 mg/kg

HLB

application(s)

advanced drug delivery

functional group

carboxylic acid

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

설명

General description

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Application

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Biochem/physiol Actions

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Features and Benefits

Suitable for Cell Biology and Biochemical Research
Can be used in Electrophoresis, DNA and RNA purification
Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
High purity product for research applications

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

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프로토콜

LPL Activity Assay Protocol

Lipoprotein lipase (LPL) hydrolyzes triglycerides associated with VLDL.

문서

Simple Digestion Protocol for Proteomics Sample Prep

Rapid trypsin digest kit yields reliable results in less than 2 hours for mass spectrometry analysis.

Selective dissociation of histones from chromatin by sodium deoxycholate.

J E Smart et al.

Journal of molecular biology, 58(3), 651-659 (1971-06-28)

Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats.

Y L Lo et al.

Biochemical pharmacology, 59(6), 665-672 (2000-02-25)

The effects of sodium deoxycholate (Deo-Na), a bile salt, and sodium caprate (Cap-Na), a fatty acid, on the transport of epirubicin were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat

Solubilization of the Semliki Forest virus membrane with sodium deoxycholate.

A Helenius et al.

Biochimica et biophysica acta, 436(2), 319-334 (1976-06-17)

The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration and causes lysis of the viral membrane at 0.9 +/-

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국제 무역 품목 번호

SKU	GTIN
30970-500G	04061826676257
30970-100G	04061826676233
30970-25G	04061835541249