16758
Poloxamer 407
purified, non-ionic
동의어(들):
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
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제품정보 (DICE 배송 시 비용 별도)
Quality Level
form
powder
quality
purified
impurities
≤1.0% water
pH
5.0-7.5
solubility
soluble, clear, colorless
cation traces
Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
UV absorption
λ: 260 nm Amax: ≤0.3, λ: 280 nm Amax: ≤0..2
suitability
no residue for filter test
storage temp.
2-8°C
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
General description
Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).
Application
Poloxamer 407 has been used:
- as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
- for VLDL secretion assay in mice
- to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production
Biochem/physiol Actions
Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| I6758-10G | 04061835367061 |
| I6758-1G | 04061835367078 |
| I6758-5G | 04061835367085 |
| 420290-5GM | 04055977210828 |
| 420291-1GM | 04055977210835 |
| 420291-5GM | 07790788050108 |
| 420322-10GM | 07790788055622 |
| 420322-500GM | 07790788050153 |
| 70527-3 | 07790788052690 |
| 420322-100GM | 07790788050146 |
| 420322-1GM | 04055977210552 |
| 420322-25GM | 07790788057817 |
| 420322-5GM | 04055977210620 |