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Merck

PHR1141

Supelco

Ondansetron Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Ondansetron hydrochloride dihydrate, 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C18H19N3O · HCl · 2H2O
CAS 번호:
103639-04-9
Molecular Weight:
365.85
MDL number:
MFCD00374371
UNSPSC 코드:
41116107
PubChem Substance ID:
329823161
NACRES:
NA.24

주요 문서

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기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000218
traceable to USP 1478582

API family

ondansetron

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-30°C

SMILES string

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

유전자 정보

human ... HTR3A(3359)

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관련 카테고리

일반 설명

Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

애플리케이션

Ondansetron Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by spectrophotometric, electrochemical, and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

5-HT3 serotonin receptor antagonist

분석 메모

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7141 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

픽토그램

Skull and crossbonesCorrosionEnvironment
GHS06,GHS05,GHS09

신호어

Danger

유해 및 위험 성명서

H301,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets
Khan S, et al.
Aaps Pharmscitech, 8(2), E127-E133 (2007)
UV spectrophotometric method for determination of ondansetron hydrochloride in pure and its formulation
Kalaichelvi R,et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 151-152 (2012)
Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential
Beg S, et al.
Colloids and Surfaces. B, Biointerfaces, 101(3), 414-423 (2013)
Determination of ondansetron hydrochloride by a liquid membrane potentiometric sensor based on room temperature ionic liquids
Faridbod F, et al.
International Journal of Electrochemical Science, 8(8), 10461-10472 (2013)
Fast dissolving sublingual films of ondansetron hydrochloride: effect of additives on in vitro drug release and mucosal permeation
Koland M, et al.
Journal of Young Pharmacists : Jyp, 2(3), 216-222 (2010)
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