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Merck

PHR1014

Supelco

Hydrocortisone

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C21H30O5
CAS 번호:
50-23-7
Molecular Weight:
362.46
Beilstein:
1354819
EC Number:
200-020-1
MDL number:
MFCD00011654
UNSPSC 코드:
41116107
PubChem Substance ID:
329823045
NACRES:
NA.24

주요 문서

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기술 서비스
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기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. H1300000
traceable to USP 1316004

API family

hydrocortisone

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

mp

211-214 °C (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-30°C

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

유전자 정보

human ... NR3C1(2908)

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관련 카테고리

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.

애플리케이션

Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

분석 메모

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360Df,H373

Hazard Classifications

Repr. 1A - STOT RE 2

표적 기관

Adrenal gland,Bone marrow

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Simultaneous determination of hydrocortisone and benzyl alcohol in pharmaceutical formulations by reversed-phase high-pressure liquid chromatography.
Rego Aand Nelson B
Journal of Pharmaceutical Sciences, 71(11), 1219-1223 (1982)
On-line post-column photochemical derivatization in liquid chromatographic− diode-array detection analysis of binary drug mixtures.
Di Pietra AM,et al
Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 1191-1199 (1996)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)
Advantages of application of UPLC in pharmaceutical analysis.
Novakova L, et al.
Talanta, 68(3), 908-918 (2006)
Margriet A B Veldhorst et al.
The Journal of clinical endocrinology and metabolism, 99(1), 285-290 (2014-01-05)
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
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