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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H21CaN7O7 · xH2O
CAS 번호:
Molecular Weight:
511.50 (anhydrous basis)
NACRES:
NA.24
UNSPSC Code:
41116107
MDL number:
Beilstein/REAXYS Number:
5723924
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
folic acid
form
solid
manufacturer/tradename
EDQM
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
InChI
1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
InChI key
KVUAALJSMIVURS-ZEDZUCNESA-L
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. Calcium folinate (CF) is a folic acid derivative. It is a naturally occurring compound that has a vital role in various metabolic pathways. Calcium folinate (CF) drug is also used in the treatment of anemia, during pregnancy.
Application
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
LC- MS characterization of trace impurities contained in calcium folinate
Francese G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 757-763 (2005)
Na Yeon Han et al.
Radiology, 271(2), 416-425 (2014-01-31)
To retrospectively evaluate findings of chemotherapy-induced focal hepatopathy (CIFH) on gadoxetic acid-enhanced magnetic resonance (MR) and diffusion-weighted (DW) images and to determine imaging features that are most helpful in differentiating CIFH from metastasis. This retrospective study was approved by the
Zheng-mao Lu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(4), 2941-2948 (2013-12-10)
Polymorphisms in the excision repair cross-complimentary group 1 (ERCC1)-excision repair cross-complimentary group 4 (ERCC4) genes have been implicated in the prognosis of various cancers. We conducted a cohort study to investigate the role of ERCC1-ERCC4 gene polymorphisms on the response
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| C0250000 | 04061833792087 |