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Merck

94687

Everolimus

analytical standard

동의어(들):

42-O-(2-Hydroxyethyl)rapamycin

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C53H83NO14
CAS 번호:
Molecular Weight:
958.22
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
기술 서비스
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grade

analytical standard

Quality Level

assay

≥75.0% (qNMR)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

−20°C

SMILES string

O=C(C([C@@]1(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C2=O)([H])O1)=O)N3[C@H](C(O[C@@]([C@@H](C[C@@]4([H])C[C@@H](OC)[C@H](OCCO)CC4)C)([H])CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)=O)CCCC3

InChI

1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChI key

HKVAMNSJSFKALM-GKUWKFKPSA-N

Gene Information

human ... FKBP1A(2280)

General description

Everolimus (RAD001), a derivative of rapamycin, is commonly used as a drug for the inhibition of the mTOR pathway, affecting tumor cell division and angiogenesis.

Application

Everolimus may be used as a standard in the following clinical studies:
  • Investigation of its glucose-dependent growth-inhibitory property in breast cancer cell lines.
  • Evaluate its possible antiproliferative effects in human bronchial carcinoids in primary culture.



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pictograms

Health hazardEnvironment

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Kidney,Testes

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문



Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells
Ariaans G, et al.
BMC Cancer, 17(1), 232-232 (2017)



국제 무역 품목 번호

SKUGTIN
94687-10MG04061834079590