생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
rat, guinea pig, mouse
제조업체/상표
Chemicon®
기술
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... TAC1(6863)
일반 설명
35 kDa
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
면역원
Epitope: C terminus
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
애플리케이션
Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
생화학적/생리학적 작용
Specific for the Substance P Receptor (NK-1).
물리적 형태
Rabbit polyclonal serum containing no preservative.
Unpurified
제조 메모
Stable for 1 year at -20ºC from date of receipt.
분석 메모
Control
Spinal Cord, brain membrane lysate
Spinal Cord, brain membrane lysate
Evaluated by western blot on Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB5800
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Mantyh, P W, et al.
Science (New York, N.Y.), 278, 275-279 (1997)
Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells.
Vigna, S R, et al.
The Journal of Neuroscience, 14, 834-845 (1994)
A R Castro et al.
Neuroscience, 141(4), 2087-2095 (2006-07-01)
Secondary hyperalgesia in the monoarthritic rat is accompanied by a decrease in nociceptive activation of spinal neurons expressing GABA(B) receptors and by the opposite effect in the cells expressing neurokinin 1 (NK1)-receptors. In order to ascertain the relative role of
Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation.
J Palecek, V Paleckova, W D Willis
Neuroscience null
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
The Journal of Neuroscience null
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