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5.08437

Pepstatin A

Name: Pepstatin A
Brand: MM

≥98% (HPLC), aspartic proteases inhibitor, liquid

동의어(들):

InSolution Pepstatin A, Synthetic, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid, Pepstatin A, Synthetic InSolution, Pepstatin A, Synthetic InSolution, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₄H₆₃N₅O₉

CAS 번호:

26305-03-3

Molecular Weight:

685.89

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00060740

Assay:

≥98% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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속성

제품 이름

Pepstatin A, InSolution, ≥98%, Synthetic, protease inhibitor

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C

InChI

1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1

InChI key

FAXGPCHRFPCXOO-JHTFMCFMSA-N

설명

General description

Pepstatin A, a pentapeptide containing two non-proteinogenic statin residues, is a highly effective inhibitor of cathepsin D (CTSD). It also inhibits other aspartic proteases at nanomolar concentrations (with a Ki of 10-10 M). Pepstatin A is commonly utilized for mapping, purifying, or titrating CTSD. Pepstatin A is found to block the invasion of C. albicans into corneocytes in mice with cutaneous candidiasis and inhibit aspartyl proteases.

Application

Pepstatin A has been used as a negative control in enzymatic activity assays to inhibit CTSD activity in lysosomal studies involving chondrocytes.

Features and Benefits

Primary Target: aspartic proteases
Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 25 mM (10 mg/583 µL) sterile-filtered solution of Pepstatin A, Synthetic (Cat. No. 516481-M) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 4 months at -20°C. Use only fresh DMSO for further dilutions.

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.

Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.

Iva-Val-Val-Sta-Ala-Sta

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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저장 등급

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

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SKU	GTIN
5084370001	04055977261967