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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H40O7PNa
CAS 번호:
Molecular Weight:
446.49
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
제품 이름
17:0 Lyso PA, 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder
assay
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
form
powder
packaging
pkg of 1 × 25 mg (857127P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857127P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
General description
Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100 nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.
Application
17:0 Lyso PA is suitable to use as an internal standard:
- for mass spectrometric determination of lysophosphatidic acid molecular species in mouse peritoneal macrophages
- in the quantification of the lipid species released from extended synaptotagmin 2 (E-SYT2) expressed in mammalian cells by liquid chromatography with tandem mass spectrometry (LC-MS/MS)
- for the extraction of lipids from brain homogenate
- to extract lipids from the stomach washing solution for the determination of lysophosphatidic acid in a mouse stomach fluid
Biochem/physiol Actions
Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).
Packaging
5 mL Amber Glass Screw Cap Vial (857127P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2\beta (group VIA phospholipase A2)
Ashley JW, et al.
The Journal of Biological Chemistry, 291(44), 23268-23281 (2016)
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro
Afroz S, et al.
Prostaglandins & other lipid mediators, 135, 36-44 (2018)
Comprehensive phospholipid and sphingomyelin profiling of different brain regions in mouse model of anxiety disorder using online two-dimensional (HILIC/RP)-LC/MS method
Berkecz R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 149, 308- 317 (2018)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 857127P-25MG | 04061835231935 |