850371P
Avanti
22:0 PC
Avanti Research™ - A Croda Brand
동의어(들):
1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C52H104NO8P
CAS 번호:
Molecular Weight:
902.36
MDL number:
UNSPSC 코드:
51191904
NACRES:
NA.25
제품 이름
22:0 PC, 1,2-dibehenoyl-sn-glycero-3-phosphocholine, powder
분석
>99% (TLC)
양식
powder
포장
pkg of 1 × 1 g (850371P-1g)
pkg of 1 × 25 mg (850371P-25mg)
pkg of 1 × 500 mg (850371P-500mg)
제조업체/상표
Avanti Research™ - A Croda Brand 850371P
지질 유형
phospholipids
cardiolipins
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)=O
InChI
1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3
InChI key
HRTBOPUWPUXROO-UHFFFAOYSA-N
일반 설명
Phosphatidylcholines (PCs) are amphipathic molecules, that are mainly located on the outer leaflets of the biological membrane bilayer. Approximately 40–50% of the total cellular phospholipids consists of phosphatidylcholine.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
애플리케이션
22:0 PC may be used:
- to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
- to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
- as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)
생화학적/생리학적 작용
Phosphatidylcholines (PCs) can serve as lung surfactant.
포장
20 mL Clear Glass Screw Cap Vial (850371P-1g)
20 mL Clear Glass Screw Cap Vial (850371P-500mg)
5 mL Amber Glass Screw Cap Vial (850371P-25mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
Bingbing Cheng et al.
Scientific reports, 9(1), 20020-20020 (2019-12-29)
Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may be important for facilitating the clinical adoption of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening, both to ensure safe acoustic exposures, and to achieve repeatable and consistent opening.
Estelle Beguin et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 23-33 (2019-11-17)
Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
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