791637C
Avanti
15:0-18:1-d7-PC
Avanti Research™ - A Croda Brand
동의어(들):
1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C41H73 D7 NO8 P
CAS 번호:
Molecular Weight:
753.09
MDL number:
UNSPSC 코드:
41141825
NACRES:
NA.25
분석
>99% (TLC)
양식
liquid
포장
pkg of 1 × 1 mL (791637C-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand
농도
1 mg/mL (791637C-1mg)
배송 상태
dry ice
저장 온도
−20°C
일반 설명
15:0-18:1-d7-PC (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine) is a deuterated phospholipid. The lipid comprises phosphatidylcholine attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phospholipids, in general are amphiphilic and have phosphocholine moiety attached to sn-3 position of glycerol. Phosphatidylcholine is a glycerophospholipid and is a cell membrane component.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.
애플리케이션
15:0-18:1-d7-PC (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphocholine) has been used:
- as a component of extraction solvent for lipid isolation from biological samples
- as an internal standard for spiking serum samples for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
- as an internal standard in analysis of lipids from cystic fibrosis derived cell lines
생화학적/생리학적 작용
Phosphatidylcholine (PC) levels are crucial for mediating various cellular processes including membrane movement and cell differentiation. A disturbance in PC levels is implicated in various metabolic disorders.
포장
2 mL Amber Glass Sealed Ampule (791637C-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC
신호어
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
표적 기관
Central nervous system, Liver,Kidney
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point (°F)
does not flash
Flash Point (°C)
does not flash
Alessandra Mingione et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 110-125 (2020-01-31)
Cystic Fibrosis (CF) is an inherited disease associated with a variety of mutations affecting the CFTR gene. A deletion of phenylalanine 508 (F508) affects more than 70% of patients and results in unfolded proteins accumulation, originating a proteinopathy responsible for
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using
Luce Farine et al.
Scientific reports, 5, 16787-16787 (2015-11-19)
Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are among the most abundant phospholipids in biological membranes. In many eukaryotes, the CDP-ethanolamine and CDP-choline branches of the Kennedy pathway represent major and often essential routes for the production of PE and PC, with
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