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KITALYSIS-CN

KitAlysis High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

동의어(들):

Amination Screening Kit, Buchwald-Hartwig Amination

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크기 선택

보기 변경

제품정보 (DICE 배송 시 비용 별도)

NACRES:
NA.22
UNSPSC Code:
12161503
기술 서비스
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도움 문의


product line

KitAlysis

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Cross Couplings, reagent type: catalyst
core: palladium

storage temp.

room temp

General description

The KitAlysis High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC


키트 구성품 전용

제품 번호
설명

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

키트 구성품 역시 별도로 이용 가능함

제품 번호
설명
SDS & 가격

  • N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL
    SDS

  • 1,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL
    SDS

  • Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL
    SDS

  • Josiphos SL-J009-1 Pd G3 5 µmol
    SDS

  • SPhos Pd G2 5 µmol
    SDS

  • RuPhos Pd G2 5 µmol
    SDS

  • P(t-Bu)3 Pd G2 5 µmol
    SDS

모두 보기 (15)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

target_organs

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

저장 등급

4.2 - Pyrophoric and self-heating hazardous materials

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

wgk

WGK 3

supp_hazards



가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 문서 section.

도움이 필요하시면 연락하세요. 고객 지원 부서

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문


프로토콜

Catalyst screening kits, KitAlysis™, and TLC-MS analysis enable high-throughput synthesis and analysis for efficient reactions.

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

모든 프로토콜 보기

문서

All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Preformed catalysts in the kit are stable but become air-sensitive when activated; Schlenk technique aids scale-up.

모든 기사 보기

관련 콘텐츠

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

유기 합성의 화학 반응 설계 및 최적화는 반응 파라미터를 정밀하게 변경하여 표적 분자에 대한 경로를 찾는 데 최적의 결과를 얻는 것을 목표로 합니다.


High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in



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SKUGTIN
KITALYSIS-CN-1KT04061833945223