911771
Lenalidomide-Photoswitch1-NH2 hydrochloride
≥95%
동의어(들):
(E)-N-(4-Aminobutyl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetamide hydrochloride, PHOTAC template, Photoswitchable protein degrader building block for PROTAC® research
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C27H32N6O7 · xHCl
CAS 번호:
Molecular Weight:
552.58 (free base basis)
MDL number:
UNSPSC Code:
12352101
ligand
lenalidomide
Quality Level
assay
≥95%
form
powder or crystals
reaction suitability
reactivity: carboxyl reactive, reagent type: ligand-linker conjugate
availability
available only in USA
functional group
amine
storage temp.
2-8°C
SMILES string
NCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C4C(NC(CC4)=O)=O)C3=O)C=C1OC)=O.Cl
InChI
1S/C27H32N6O7.ClH/c1-38-21-12-16(13-22(39-2)25(21)40-15-24(35)29-11-4-3-10-28)31-32-19-7-5-6-17-18(19)14-33(27(17)37)20-8-9-23(34)30-26(20)36;/h5-7,12-13,20H,3-4,8-11,14-15,28H2,1-2H3,(H,29,35)(H,30,34,36);1H/b32-31+;
InChI key
BEBAPHRSEIHKIQ-MRRLHAJBSA-N
Application
Learn more: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationProtein degrader building block Lenalidomide-Photoswitch1-NH2 hydrochloride enables the synthesis of PHOtochemically TArgeting Chimeras (PHOTACs), or photoswitchable proteolysis-targeting chimeras (PROTACs) that can be reversibly activated with different wavelengths of light. Developed in the Trauner and Pagano labs, PHOTACs are inactive in the dark but are activated to the cis isomer via irradiation at 390 nm and reversibly deactivated at wavelengths >450 nm. As described in Reynders, et al, this conjugate was used to prepare PHOTAC-I-3 and contains a Cereblon (CRBN)-recruiting ligand, an azobenzene photoswitchable crosslinker, and pendant amine for reactivity with an acid on the target warhead. Light-mediated control of the resulting PHOTAC affords advanced temporal and spatial control of targeted protein degradation.
Suggested wavelengths for photoswitching:
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Learn more:
Suggested wavelengths for photoswitching:
- Switch to cis isomer: 390 nm (380-400 nm)
- Switch to trans isomer (thermally more stable isomer): >450 nm
Low-intensity light needed for photoactivation is not cytotoxic.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Learn more:
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 911771-50MG | 04061841846710 |