901906
SPhos
95%, powder or crystals
동의어(들):
2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, S Phos
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제품정보 (DICE 배송 시 비용 별도)
제품 이름
SPhos, 95%
assay
95%
form
powder or crystals
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings, reagent type: ligand
greener alternative product characteristics
Catalysis
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sustainability
Greener Alternative Product
mp
164-166 °C (lit.), 165.5 °C
functional group
phosphine
greener alternative category
General description
SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
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Application
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
SPhos may be used as a ligand in the following processes:
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
- Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation
Legal Information
Usage subject to Patents: US 6307087; EP 1097158; JP 5758844; CA 2336691
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRa agonists.
Hioki H, et al.
Bioorganic & Medicinal Chemistry Letters, 19(3), 738-741 (2009)
Seel S, et al.
Journal of the American Chemical Society, 133(13), 4774-4777 (2011)
Sustainable Fe?ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water
Handa, Sachin, et al.
Science, 349.6252, 1087-1091 (2015)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 901906-1G | 04061835511150 |
| 901906-250G | 04061835519859 |
| 901906-25G | 04061835559947 |
| 901906-5G | 04061835511181 |