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367532

5-Chloro-1-methyl-4-nitroimidazole

Name: 5-Chloro-1-methyl-4-nitroimidazole
Brand: ALDRICH

98%

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄H₄ClN₃O₂

CAS 번호:

4897-25-0

Molecular Weight:

161.55

NACRES:

NA.22

PubChem Substance ID:

24862766

UNSPSC Code:

12352100

EC Number:

225-521-2

MDL number:

MFCD00233664

Assay:

98%

기술 서비스

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도움 문의

속성

Quality Level

100

assay

98%

mp

148-150 °C (lit.)

functional group

chloro, nitro

SMILES string

Cn1cnc(c1Cl)[N+]([O-])=O

InChI

1S/C4H4ClN3O2/c1-7-2-6-4(3(7)5)8(9)10/h2H,1H3

InChI key

OSJUNMSWBBOTQU-UHFFFAOYSA-N

설명

General description

5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.

Application

5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K₂CO₃ and tetrabutylammonium bromide.

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole.

M E Watts et al.

International journal of radiation biology and related studies in physics, chemistry, and medicine, 38(6), 673-675 (1980-12-01)

Glutathione-reactive nitro compounds as radiosensitizers: mechanistic and therapeutic implications.

M E Watts et al.

International journal of radiation oncology, biology, physics, 12(7), 1135-1138 (1986-07-01)

The "extra" radiosensitization seen with GSH-reactive nitro compounds is too large to be accounted for by GSH-depletion acting independently--there must be competition. The GS-conjugate leaks out of cells slowly and is trapped at high concentrations. Its properties, such as concentration

The effect of electron-affinic radiosensitizers on ATP levels in V79 379A Chinese hamster cells.

R J Hodgkiss

Biochemical pharmacology, 36(3), 393-396 (1987-02-01)

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국제 무역 품목 번호

SKU	GTIN
367532-5G	04061831827378