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332607

(2-Hydroxypropyl)-β-cyclodextrin

Name: (2-Hydroxypropyl)-β-cyclodextrin
Brand: ALDRICH

average M_w ~1,460

동의어(들):

(2-Hydroxypropyl)-beta-cyclodextrin, HP-β-CD

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제품정보 (DICE 배송 시 비용 별도)

CAS 번호:

128446-35-5

PubChem Substance ID:

24859911

UNSPSC Code:

12352201

NACRES:

NA.22

EC Number:

420-920-1

Form:

powder

기술 서비스

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도움 문의

속성

form

powder

Quality Level

200

optical activity

[α]25/D +135°, c = 1 in H₂O (typical)

mol wt

average M_w ~1,460

extent of labeling

0.8 molar substitution

mp

267 °C (dec.)

solubility

water: 180 g/L

SMILES string

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

설명

General description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.

Application

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

(2-Hydroxypropyl)-β-cyclodextrin may be used:

As an analytical standard for the determination of the analyte in pharmaceutical formulations by thin layer chromatography (TLC) method.
To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique.
As a mobile phase additive for the effective separation of β-carbolines by HPLC.
In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous solution because of the complex between HP-β-CD and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HP-β-CD that results in enhanced solubility. HP-β-CD can be used to prepare an inclusion complex with ropivacaine (RVC) to increase the solubility of RVC for efficient drug delivery.

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문서 라이브러리 방문

Chromatographic Separation and Purification of Novel Drug Excipient 2-Hydroxypropyl-beta-Cyclodextrin [J]

Yimin Z, et al.

Chinese Journal of Analytical Chemistry, 5 (2006)

Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex.

Daniele R de Araujo et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 33(1), 60-71 (2007-11-27)

Ropivacaine (RVC) is an enantiomerically pure local anesthetic (LA) largely used in surgical procedures, which presents physico-chemical and therapeutic properties similar to those of bupivacaine (BPV), but associated to less systemic toxicity. This study focuses on the development and pharmacological

Effects of cooling rate in microscale and pilot scale freeze-drying - Variations in excipient polymorphs and protein secondary structure.

Björn-Hendrik Peters et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 95, 72-81 (2016-05-26)

Microscale freeze-drying makes rapid process cycles possible for early-stage formulation development. To investigate the effects of equipment scale and cooling rate on the solid state properties and the protein's secondary structure of a sample, three binary formulations of catalase were

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국제 무역 품목 번호

SKU	GTIN
332607-100G	04061826736883
332607-25G	04061826736890
332607-500G	04061826736906
332607-5G	04061826736920

주요 문서

(2-Hydroxypropyl)-β-cyclodextrin

average M_w ~1,460

크기 선택

제품정보 (DICE 배송 시 비용 별도)

form

Quality Level

optical activity

mol wt

extent of labeling

mp

solubility

SMILES string

InChI

InChI key

General description

Application

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안전성 정보

wgk

flash_point_f

flash_point_c

ppe

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국제 무역 품목 번호

주요 문서

(2-Hydroxypropyl)-β-cyclodextrin

average Mw ~1,460

크기 선택

제품정보 (DICE 배송 시 비용 별도)

form

Quality Level

optical activity

mol wt

extent of labeling

mp

solubility

SMILES string

InChI

InChI key

General description

Application

Still not finding the right product?

안전성 정보

wgk

flash_point_f

flash_point_c

ppe

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문서

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국제 무역 품목 번호

average M_w ~1,460