286583
5-Methoxytryptamine
97%
동의어(들):
2-(5-Methoxyindol-3-yl)ethylamine, 3-(2-Aminoethyl)-5-methoxyindole, 5-MOT, 5-Methoxyindole-3-ethanamine, Deacetylmelatonin, NSC 56422
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H14N2O
CAS 번호:
Molecular Weight:
190.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-153-7
Beilstein/REAXYS Number:
145587
MDL number:
Assay:
97%
Form:
solid
Quality Level
assay
97%
form
solid
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
mp
121-123 °C (lit.)
functional group
amine
SMILES string
COc1ccc2[nH]cc(CCN)c2c1
InChI
1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
InChI key
JTEJPPKMYBDEMY-UHFFFAOYSA-N
Gene Information
human ... HTR1A(3350), HTR2A(3356), HTR2C(3358)
rat ... Htr2a(29595), Htr2c(25187), Htr7(65032)
General description
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Application
5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.
Reactant for preparation of:
- Carboline disaccharide domain of shishijimicin A
- Melatonin analogs for the reduction of intraocular pressure
- 5-HT4 receptor ligands
- inhibitors of sortase A and isocitrate lyase
- Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
- Aurora and epidermal growth factor receptor kinase inhibitors
- Agents for the treatment of human papillomavirus infection
- Manzamine analogues for the control of neuroinflammation and cerebral infections
- Inhibitors of pro-inflammatory cytokines
- Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Amir Hanna-Elias et al.
European journal of medicinal chemistry, 44(7), 2952-2959 (2009-02-19)
Twenty-three indole-3-methanamines were designed, synthesized and evaluated as ligands for the 5-HT(4) receptor. Compounds I-d, I-j, I-o, I-q and I-u showed good affinity at 100 microM and I-o was found to be only 5-fold less potent than the agonists serotonin
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
Janjetovic Z, Nahmias ZP, Hanna S, et al.
Journal of Pineal Research, 57(1), 90-102 (2014)
Rut Vleugels et al.
PloS one, 8(5), e65052-e65052 (2013-06-07)
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors. However, a lack of pharmacological knowledge impedes studies on invertebrate 5-HT receptors. Moreover, pharmacological information is urgently needed in
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 286583-1G | 04061826264751 |
| 286583-100MG | 04061826264744 |