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Merck

CCND1

cyclin D1

동의어:
BCL1, D11S287E, PRAD1, U21B31
:
UniProtKB ID:
Clone ID:
  • Human(595) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
  • Mouse(12443) cyclin D1
  • Rat(58919) cyclin D1
  • naked mole-rat(101712621) cyclin D1
  • domestic guinea pig(100729808) cyclin D1
  • sheep(100144763) cyclin D1
  • Domestic Rabbit(100009036) cyclin D1
  • Zebrafish(30222) cyclin D1
  • dog(449028) cyclin D1
  • cow(524530) cyclin D1
  • domestic cat(100037407) cyclin D1
  • chicken(396341) cyclin D1

Custom & Knockdown Gene Products

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-CYCLIN D1 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
Monoclonal Anti-CCND1 antibody produced in mouse, clone CD1.1, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human, rat
응용분야
flow cytometry
Anti-Cyclin D1 Antibody, clone 1J9, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
human, monkey
응용분야
immunocytochemistry
immunohistochemistry

western blot
Anti-Cyclin D1/2 Antibody, clone 5D4, clone 5D4, Upstate®, from mouse,
종별 반응성
hamster, human, mouse, rat
응용분야
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-phospho-Cyclin D1 (pThr286) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot

Small Molecule - Inhibitor

제품 번호
설명
PD 0332991 isethionate, ≥98% (HPLC),
human

Proteins

제품 번호
설명
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
human
CDK4/Cyclin D1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human CCND1,
human
MISSION® esiRNA, targeting mouse Ccnd1,
mouse