SAB2501384
Anti-CSF1R antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-C-FMS, Anti-CD115, Anti-CSFR, Anti-FIM2, Colony stimulating factor 1 receptor
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
canine, rat, human, mouse
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CSF1R(1436)
General description
CSF1R (colony stimulating factor 1 receptor) or FMS, acts as a receptor for CSF1, and regulates monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
Immunogen
Peptide with sequence KNIHLEKKYVR, from the internal region of the protein sequence according to NP_005202.2
Biochem/physiol Actions
CSF1R (colony stimulating factor 1 receptor), and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.
Konno T
Neurology (2014)
Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGF? in claudin-low breast tumor cells.
Patsialou A
Oncogene (2015)
Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells.
Barbetti V
Oncogene (2014)
CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function.
Pridans C
Scientific Reports (2013)
Myew-Ling Toh et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(11), 2989-3000 (2014-03-14)
Colony-stimulating factor 1 receptor (CSF-1R) essentially modulates monocyte proliferation, migration, and activation, which are considered important for the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine CSF-1R expression in human RA as well as the efficacy of
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