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Merck

CSF1R

colony stimulating factor 1 receptor

Synonyms:
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species:
UniProtKB ID:
Gene ID:
  • Human(1436) Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
  • Mouse(12978) colony stimulating factor 1 receptor
  • Rat(307403) colony stimulating factor 1 receptor
  • chicken(396406) colony stimulating factor 1 receptor
  • dog(489188) colony stimulating factor 1 receptor
  • cow(509418) colony stimulating factor 1 receptor
  • Horse(100060422) colony stimulating factor 1 receptor
  • domestic cat(493706) colony stimulating factor 1 receptor
  • domestic guinea pig(100726053) colony stimulating factor 1 receptor
  • naked mole-rat(101719513) colony stimulating factor 1 receptor
  • sheep(101109969) colony stimulating factor 1 receptor

Custom & Knockdown Gene Products

ELISA

Product Number
Description
Species
Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CSF1R antibody produced in mouse, clone 1G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay

western blot
Anti-phospho-CSFR (pTyr708) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-M-CSF Receptor antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98, clone AFS98, 0.2 mg/mL, from rat,
Species Reactivity
mouse
Application
flow cytometry
western blot
Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98, clone AFS98, 0.2 mg/mL, from rat,
Species Reactivity
mouse
Application
flow cytometry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Pazopanib, ,
Species
human

Proteins

Product Number
Description
Species
Fms (Y969C) Protein, active, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CSF1R,
Species
human
MISSION® esiRNA, targeting mouse Csf1r,
Species
mouse