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PHR1342

Sucralose

Name: Sucralose
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

4-chloro-4-désoxy-α-D-galactose de 1,6-dichloro-1,6-didésoxy-β-D-fructofurannosyle, E955, Trichlorosucrose

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₂H₁₉Cl₃O₈

Numéro CAS:

56038-13-2

Poids moléculaire :

397.63

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823327

MDL number:

MFCD03648615

Beilstein/REAXYS Number:

3654410

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Propriétés

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001344, traceable to USP 1623626

API family

sucralose

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl

InChI

1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1

InChI key

BAQAVOSOZGMPRM-QBMZZYIRSA-N

Description

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.

Application

Sucralose may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Un exhausteur de goût sucré de synthèse, détectable par l'être humain. Active les récepteurs du goût sucré T1R2/T1R3 sur les cellules entéroendocrines et déclenche une sécrétion hormonale accrue de glucagon-like peptide-1 (GLP-1) et de peptide insulinotrope dépendant du glucose (GIP).

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA1094 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Evaluating the taste masking effectiveness of various flavors in a stable formulated pediatric suspension and solution using the [TM="Astree"] electronic tongue

Campbell GA, et al.

Powder Technology, 224(25), 109-123 (2012)

Physicochemical and microbiological stabilities of a sweetened and calorie-free metformin extemporaneous formulation for pediatrics

Alemon-Medina R, et al.

Latin American Journal of Pharmacy, 31(25), 1253-1260 (2012)

Comprehensive analysis of pharmaceutical products using simultaneous mixed-mode (ion-exchange/reversed-phase) and hydrophilic interaction liquid chromatography

Kazarian AA, et al.

Journal of Separation Science, 37(16), 2138-2144 (2014)

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Numéro d'article de commerce international

Référence	GTIN
PHR1342-500MG	04061835233731