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77626

N-tert-butyldiméthylsilyl-N-méthyltrifluoroacétamide

derivatization grade (GC derivatization), LiChropur™, ≥98.0% (GC)

Synonyme(s) :

MTBSTFA

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A propos de cet article

Formule linéaire :
CF3CON(CH3)Si(CH3)2C(CH3)3
Numéro CAS:
77377-52-7
Poids moléculaire :
241.33
NACRES:
NA.22
UNSPSC Code:
12352111
Beilstein/REAXYS Number:
3606546
MDL number:
MFCD00009671
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grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥98.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.402 (lit.)

bp

172-175 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.

Application

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide may be used as a derivatizing reagent for the determination of methionine sulfoxide and methionine in blood plasma and chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils using gas-chromatography coupled to mass spectrometry technique.

Other Notes

Discover LiChropur™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Classe de stockage

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number

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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Advanced Gas Chromatography: Progress in Agricultural, Biomedical and Industrial Applications (2012)
Ryuichi Mashima et al.
Analytical biochemistry, 313(1), 28-33 (2003-02-11)
Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species via 2-electron-dependent mechanism. Such oxidants can be generated from activated neutrophils; therefore, methionine sulfoxide can be regarded as a biomarker of oxidative stress in vivo. We describe here
Two stage derivatization with N-(tert.-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) and N-methyl-bis-(trifluoroacetamide)(MBTFA) for the gas-chromatographic analysis of OH-, SH-and NH-compounds
Schoene K, et al.
Fresenius Journal of Analytical Chemistry, 348(5-6), 364-370 (1994)

Numéro d'article de commerce international

RéférenceGTIN
77626-10ML04061838593061
77626-10X1ML04061838593078
77626-1ML-KC04061838593085