902691
Hydroxy-PEG5-t-butyl ester
Synonyme(s) :
tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
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A propos de cet article
Formule empirique (notation de Hill) :
C17H34O8
Numéro CAS:
Poids moléculaire :
366.45
UNSPSC Code:
51171641
MDL number:
Assay:
≥95%
Form:
liquid
Service technique
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≥95%
form
liquid
reaction suitability
reagent type: cross-linking reagent
refractive index
n/D 1.448
density
1.071
functional group
ester, hydroxyl
storage temp.
−20°C
SMILES string
O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO
Application
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Jordan H Wosnick et al.
Journal of the American Chemical Society, 127(10), 3400-3405 (2005-03-10)
A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic solvents and have photophysical properties
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 902691-1G | 04061838694744 |
| 902691-250MG | 04061838694751 |