1012065
USP
Acyclovir
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
Acycloguanosine, 9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir
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About This Item
Empirical Formula (Hill Notation):
C8H11N5O3
CAS Number:
Molecular Weight:
225.20
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
acyclovir
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
NC1=Nc2c(ncn2COCCO)C(=O)N1
InChI
1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChI key
MKUXAQIIEYXACX-UHFFFAOYSA-N
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General description
Acyclovir is a nucleoside analogue antiviral drug. It is a highly potent inhibitor of herpes simplex virus. It is related to cytarabine, idoxuridine, trifluridine and vidarabine.
Application
Acyclovir USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Acyclovir Capsules
- Acyclovir for Injection
- Acyclovir Injection
- Acyclovir Ointment
- Acyclovir Oral Suspension
- Acyclovir Tablets
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ahlem Ben Sassi et al.
The Indian journal of medical research, 127(2), 183-192 (2008-04-12)
Tunisian Chrysanthemum species are known to have medicinal activity and some of the species are used in traditional medicine. We have earlier shown the use of C. trifurcatum flowerheads in Tunisian traditional medicine to treat constipation. In the present study
G B Elion
The American journal of medicine, 73(1A), 7-13 (1982-07-20)
Acyclovir, an acrylic purine nucleoside analog, is a highly potent inhibitor of herpes simplex virus (HSV), types 1 and 2, and varicella zoster virus, and has extremely low toxicity for the normal host cells. This selectivity is due to the
Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles.
Tavares, Guilherme Diniz, et al.
Quimica nova, 35.1, 203-206 (2012)
D M Richards et al.
Drugs, 26(5), 378-438 (1983-11-01)
Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. In common with these earlier antivirals, acyclovir is active against some members of the herpesvirus group of DNA viruses. The efficacy of topical acyclovir has
Todd Hatchette et al.
The Pediatric infectious disease journal, 27(1), 75-77 (2007-12-29)
The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A
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