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T3955

Sigma-Aldrich

TNP

≥95% (HPLC), IP6K inhibitor, powder

Synonym(s):

N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine; N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine

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About This Item

Empirical Formula (Hill Notation):
C20H16F3N7O2
CAS Number:
519178-28-0
Molecular Weight:
443.38
MDL number:
MFCD16875436
UNSPSC Code:
12352200
PubChem Substance ID:
329826781
NACRES:
NA.77

Key Documents

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Product Name

TNP, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: ≥10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

InChI key

DDSBPUYZPWNNGH-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Potent and selective IP6K inhibitor; less selective inhibitor of IP3K.
TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

TNP is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
115M4602V
013M4608V
010M4609

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Maxime Dupin et al.
PloS one, 6(6), e20957-e20957 (2011-06-28)
Many distribution models developed to predict the presence/absence of invasive alien species need to be fitted to a training dataset before practical use. The training dataset is characterized by the number of recorded presences/absences and by their geographical locations. The
Joerg U Eberle et al.
The Journal of investigative dermatology, 139(9), 1957-1965 (2019-03-27)
The mechanisms leading to allergic skin inflammation, such as atopic dermatitis or urticaria, are poorly defined. Here we used a mouse model for IgE-dependent chronic allergic inflammation to study the role of basophils and eosinophils for induction of pathology. FcεRI
Takashi Nakagata et al.
Medicina (Kaunas, Lithuania), 55(7) (2019-07-10)
Background and objectives: Exercise can help ease withdrawal symptoms of smokers. However, there is little information about the physiological responses, such as cardiorespiratory and lactate (La) responses, during exercise from light to moderate intensity combined with transdermal nicotine patches (TNPs)
Jo-Anne E Cavanagh et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 342-349 (2018-02-11)
The use of biosolids as a soil conditioner and fertiliser is hindered by the limited knowledge on the risks of micro-contaminants they contain. This study investigated the binding of six organic contaminants commonly found in biosolids, to the estrogen (ER)
Natalie E Nieuwenhuizen et al.
PLoS neglected tropical diseases, 7(8), e2395-e2395 (2013-09-07)
Nematode secreted haemoglobins have unusually high affinity for oxygen and possess nitric oxide deoxygenase, and catalase activity thought to be important in protection against host immune responses to infection. In this study, we generated a monoclonal antibody (48Eg) against haemoglobin
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