SRP0418
WDR5 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)
Synonym(s):
BIG-3, SWD3, WD Repeat Domain 5
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
37.5 kDa
packaging
pkg of 100 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... WDR5(11091)
General description
Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3 (GenBank Accession No. NM_017588) amino acids 2-334 (end) with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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WDR5, a complexed protein.
Raymond C Trievel et al.
Nature structural & molecular biology, 16(7), 678-680 (2009-07-07)
Yan-Yi Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(2), 815-820 (2010-01-19)
Viral infection causes activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. The mitochondrial outer membrane protein VISA acts as a critical adapter for assembling a virus-induced complex that
Zain Odho et al.
The Journal of biological chemistry, 285(43), 32967-32976 (2010-08-19)
Histone modification is well established as a fundamental mechanism driving the regulation of transcription, replication, and DNA repair through the control of chromatin structure. Likewise, it is apparent that incorrect targeting of histone modifications contributes to misregulated gene expression and
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