SRP0381
EZH2 /EED/SUZ12/RbAp48/AEBP2 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
48 kDa (RbBP5)
51 kDa (EED)
53 kDa (AEBP2)
86 kDa (EZH2)
87 kDa (SUZ12)
packaging
pkg of 20 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AEBP2(121536), EED(8726), EZH2(2146), RBBP4(5928), SUZ12(23512)
General description
Mutant version of EZH2 5 member complex, with a Tyr- to-Ser mutation on amino acids 646 of the EZH2 protein (GenBank Accession No. NM_004456). This mutation is often cited in the scientific literature as Y641S in variant 3 (GenBank Accession No. NM_001203247).
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ryan D Morin et al.
Nature genetics, 42(2), 181-185 (2010-01-19)
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-kappaB pathway that contribute to the activated B-cell
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