SML4249
EPZ020411
≥98% (HPLC)
Synonym(s):
EPZ 020411, EPZ-020411, N1,N2-Dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-1,2-ethanediamine (ACI)
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About This Item
Empirical Formula (Hill Notation):
C25H38N4O3
CAS Number:
Molecular Weight:
442.59
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
(Oil (syrup))
color
colorless to faint brown
storage temp.
-10 to -25°C
Biochem/physiol Actions
EPZ020411 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 10 nM; PRMT1/8 IC50 = 119/223 nM). EPZ020411 inhibits PRMT6 expression-induced H3R2 methylation in A375 cells (IC50 = 637 nM), but not PRMT1-specific methylmark (IC50 = 7.1 μM).
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