SML4175
TH-Z145
≥90% (HPLC), powder, geranylgeranyl diphosphate synthase inhibitor
Synonym(s):
(2-(3-(Octyloxy)phenyl)ethane-1,1-diyl)bis(phosphonic acid), P,P′-[2-[3-(Octyloxy)phenyl]ethylidene]bis[phosphonic acid]
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About This Item
Empirical Formula (Hill Notation):
C16H28O7P2
CAS Number:
Molecular Weight:
394.34
MDL number:
Quality Level
assay
≥90% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O
General description
TH-Z145 is a potent and selective geranylgeranyl diphosphate synthase(GGPPS) inhibitor (IC50 = 210 nM; FPPS IC50 > 30 µM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z145 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μgTH-Z145) and protecting against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z145). TH-Z145 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.
Application
TH-Z145 may be usedas a research tool in studies investigating the mevalonate pathway and itsimplications in various biological processes, including cancer andinflammation. It may also be used as a potent vaccine adjuvant to enhanceimmune responses by targeting the mevalonate pathway to improve the efficacy ofvaccines.
Biochem/physiol Actions
Potent and selective mevalonate (MVA) pathway geranylgeranyl diphosphate synthase (GGPPS) inhibitor that stimulates immune responses in vivo.
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