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SML0476

Sigma-Aldrich

Rabeprazole sodium

≥98% (HPLC)

Synonym(s):

2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole, Pariprazole

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About This Item

Empirical Formula (Hill Notation):
C18H20N3O3S · Na
CAS Number:
117976-90-6
Molecular Weight:
381.42
UNSPSC Code:
12352200
PubChem Substance ID:
329825431
NACRES:
NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL (clear solution)

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C

InChI

1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1

InChI key

KRCQSTCYZUOBHN-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495), ATP4B(496)

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Application

Rabeprazole sodium has been used as a proton pump inhibitor (PPI) to study its effects on spontaneous uterine contractile activity in pregnant women.

Biochem/physiol Actions

Rabeprazole sodium is gastric proton pump inhibitor. It suppresses the production of acid in the stomach by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Rabeprazole sodium has been used clinically to treat acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevent gastroinetestinal bleeds associated with NSAID use.
Rabeprazole sodium is gastric proton pump inhibitor; antiulcerative.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
113M4763V
053M4742V
092M4709V

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Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.
Shi S, Wang H, Gao H, et al.
Digestive Diseases and Sciences, 59(7), 1398-1405 (2014)
Hyun Jeong Lee et al.
The Journal of infectious diseases, 208(7), 1123-1130 (2013-06-27)
Clarithromycin-resistant Helicobacter pylori is associated with point mutations in the 23S ribosomal RNA (rRNA) gene. A total of 1232 patients participated and were divided into 2 control groups and 1 case group. Patients in the APC control group, which consisted
Tarek A Ahmed et al.
Life sciences, 110(1), 35-43 (2014-07-06)
First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing water in oil (W/O) nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that avoid drug peroral acid sensitivity and first pass effect. The influence of six factors on

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