SAB4502609
Anti-NF-κB p65 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
NFKB3, RELA, TF65, nuclear factor NF-κ-B p65 subunit, p65
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 60 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RELA(5970)
General description
Anti-NF-κB p65 antibody detects endogenous levels of total NF-κB p65 protein.
The NF-κB p65 (nuclear factor κ-light-chain-enhancer of activated B cells p65) gene is mapped to human chromosome 11q13.1. It codes for a transcription factor, a subunit of NF-κB.
Immunogen
The antiserum was produced against synthesized peptide derived from human NF-kappaB p65.
Immunogen Range: 278-327
Immunogen Range: 278-327
Application
Anti-NF-κB p65 antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
NF-κB p65 (nuclear factor κ-light-chain-enhancer of activated B cells p65) is associated with many fibrotic diseases such as liver fibrosis and cardiac fibrosis. Cell proliferation, inflammation, and apoptosis are some of the processes mediated by NF-κB p65. Dysregulation of the gene results in chronic inflammatory diseases, autoimmune disorders and cancer. NF-κB p65 plays an important role in NF-κB signaling.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis.
Chen S
Cell Death & Disease, 8(3), 1-13 (2017)
The role of hyperuricemia on vascular endothelium dysfunction.
Zhen H and Gui F
Biomedical Reports, 7(4), 325-330 (2017)
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNF? stimulation regulates DNA binding and transcription.
Lanucara F
Open Biology, 6(7)., 1-14 (2016)
Danshensu protects against ischemia/reperfusion injury and inhibits the apoptosis of H9c2 cells by reducing the calcium overload through the p-JNK-NF-?B-TRPC6 pathway.
Meng Y
International Journal of Molecular Medicine, 37(1), 258-266 (2016)
C11orf95-RELA fusions drive oncogenic NF-?B signalling in ependymoma.
Parker M
Nature, 506(7489), 451-455 (2014)
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