SAB4501597
Anti-JAK1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
JAK-1, JAK1, JAK1A, Janus kinase 1, kinase Jak1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 131 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JAK1(3716)
General description
Anti-JAK1 Antibody detects endogenous levels of total JAK1 protein.
Janus kinase 1 (JAK1) is a non-receptor tyrosine kinase, that belongs to the JAK family. It is located on human chromosome 1p31.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human JAK1.
Immunogen Range: 988-1037
Immunogen Range: 988-1037
Biochem/physiol Actions
Mutations in janus kinase 1 (JAK1) results in leukemia, breast cancer, lung cancer and HCC (hepatocellular carcinoma). It participates in signaling with many cytokines. JAK1 is also involved in the immune response and the initiation of allergic airway disease.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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JAK1 (Janus kinase 1) .
Knoops L, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis.
Shen Y, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 34(2), 124-129 (2016)
Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
Yang S et al
Oncotarget, 7(5), 5461-5469 (2016)
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