SAB4501408
Anti-HNF4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
HNF-4, HNF-4-α, HNF4, HNF4A, Hepatocyte nuclear factor 4-α
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 52 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HNF4A(3172)
General description
Anti-HNF4 Antibody detects endogenous levels of total HNF4 protein.
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor, located on human chromosome 20q13.12.
Immunogen
The antiserum was produced against synthesized peptide derived from human HNF4 alpha.
Immunogen Range: 280-329
Immunogen Range: 280-329
Biochem/physiol Actions
Hepatocyte nuclear factor 4 alpha (HNF4α) plays an important role in the growth of liver. Mutations in HNF4α results in maturity onset diabetes of the young (MODY).
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α.
Hu X, et al.
Biochemical and Biophysical Research Communications, 478(2), 791-797 (2016)
Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.
Lin WH, et al.
Diabetologia, 49(6), 1214-1221 (2006)
The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes.
Laver TW, et al.
Diabetes, 65(10), 3212-3217 (2016)
Katharina Prestin et al.
American journal of physiology. Renal physiology, 307(9), F1041-F1051 (2014-09-12)
Renal tubular handling of urate is realized by a network of uptake and efflux transporters, including members of drug transporter families such as solute carrier proteins and ATP-binding cassette transporters. Solute carrier family 2, member 9 (SLC2A9), is one key
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