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SAB4300462

Anti-C-RAF antibody

Name: Anti-C-RAF antibody
Brand: SIGMA

rabbit polyclonal

Synonym(s):

Anti-CRAF antibody produced in rabbit, Anti-NS5 antibody produced in rabbit, Anti-Raf-1 antibody produced in rabbit, Anti-c-Raf antibody produced in rabbit, Anti-v-raf-1 murine leukemia viral oncogene homolog 1 antibody produced in rabbit

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01092478

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB

Citations:

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Properties

Product Name

Anti-RAF1 (Ab-338) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~73 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(R-D-S-S-Y)

NCBI accession no.

NP_002871.1

UniProt accession no.

P04049

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAF1(5894)

Description

General description

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.

Immunogen

Peptide sequence around aa. 336-340 (R-D-S-S-Y), according to the protein RAF1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.

Qiu Zhang et al.

Journal of pharmacological sciences, 126(1), 66-76 (2014-09-05)

P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non-small-cell lung cancer (NSCLC) H460TaxR cells. Here, we

High cAMP attenuation of insulin-stimulated meiotic G2-M1 transition in zebrafish oocytes: interaction between the cAMP-dependent protein kinase (PKA) and the MAPK3/1 pathways.

Sudipta Maitra et al.

Molecular and cellular endocrinology, 393(1-2), 109-119 (2014-06-24)

High intra-cellular cyclic nucleotide (cAMP) ensures prophase-I arrest and prevent steroid-induced meiotic G2-M1 transition in full-grown oocytes; however, relatively less information is available for cAMP regulation of growth factor-stimulated signalling events in the oocyte model. Here using zebrafish oocytes, we

Global Trade Item Number

SKU	GTIN
SAB4300462-100UG	04061832704203