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MilliporeSigma

SAB4300234

Sigma-Aldrich

Anti-phospho-MAP2K1 (pThr291) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MAPKK1 antibody produced in rabbit, Anti-MEK1 antibody produced in rabbit, Anti-MKK1 antibody produced in rabbit, Anti-PRKMK1 antibody produced in rabbit, Anti-mitogen-activated protein kinase kinase 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00239713
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~45 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-R-TP-P-G

NCBI accession no.

NP_002746.1

UniProt accession no.

Q02750

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr291)

Gene Information

human ... MAP2K1(5604)

General description

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Immunogen

Peptide sequence around phosphorylation site of threonine 291 (P-R-T(p)-P-G, according to the protein MAP2K1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951411294

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Yea-Hyun Leem et al.
Neuroscience letters, 580, 163-168 (2014-08-15)
Depression is one of the most prevalent mental illnesses, and causes a constant feeling of sadness and lose of interest, which often leads to suicide. Evidence suggests that depression is associated with aberrant MEK/ERK signaling. However, studies on MEK/ERK signaling
Minjing Zou et al.
Thyroid : official journal of the American Thyroid Association, 24(8), 1256-1266 (2014-05-07)
RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We
Elena Manara et al.
Blood, 124(2), 263-272 (2014-04-04)
A rare location, t(6;11)(q27;q23) (MLL-AF6), is associated with poor outcome in childhood acute myeloid leukemia (AML). The described mechanism by which MLL-AF6, through constitutive self-association and in cooperation with DOT-1L, activates aberrant gene expression does not explain the biological differences
Qi Zhang et al.
The Journal of urology, 191(6), 1880-1888 (2014-01-18)
Mutations in the FLCN gene are responsible for fibrofolliculoma, pulmonary and renal cysts, and renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome. To explore therapeutic approaches to renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome we investigated the anticancer effects
Jessica Tilghman et al.
Cancer research, 74(11), 3168-3179 (2014-04-09)
Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance, and tumor recurrence. Therapeutic targets in GSCs are a focus of increasing interest to improve

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