SAB4200671
Anti-S-100 (β-Subunit) antibody, Mouse monoclonal
clone SH-B1, purified from hybridoma cell culture
Synonym(s):
Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse, NEF, S100, S100-B, S100beta
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.46
biological source
mouse
Quality Level
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SH-B1, monoclonal
species reactivity
cat, rabbit, porcine, bovine, rat, human
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1.5-3 μg/mL using immunoperoxidase labeling of pronase digested, formalin-fixed, paraffin-embedded sections of rabbit tongue.
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... S100B(6285)
General description
Monoclonal Anti-S-100 (β-subunit) (mouse IgG1 isotype) is derived from the SH-B1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. S-100 is a set of small, thermolabile, highly acidic homo or hetero-dimer calcium binding proteins. The protein exists in two isoforms namely, S-100α and S-100β, which are brain specific.
S-100β is a calcium binding protein. It is mainly present in astrocytes and neurons of hindbrain and spinal cord.
Immunogen
Purified bovine brain S-100β
Application
Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse has been used in:
- immunohistochemistry
- enzyme linked immunosorbent assay (ELISA) (Ca2+ ion independent)
- immunocytochemistry
- immunoblotting
- dot blot
- immunohistochemistry.
Biochem/physiol Actions
S-100 is involved in cell-growth regulation, increasing membrane permeability to cations, inflammatory response in many brain diseases, including schizophrenia, stimulation of nucleolar RNA polymerase activity and transporting proteins and free fatty acids in adipocytes. S-100β tissue distribution can be a useful tool in the differential diagnosis of neoplasms and proliferative processes.
S-100β protein interacts with synaptic, cytoskeletal and cell cycle proteins. Additionally, it can regulate calcium levels in glial and neuronal cells. It is involved in neuronal plasticity, astrogliosis and neuronal cell survival. S-100β is associated with Alzheimer disease and amyotrophic lateral sclerosis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons
Shen Y, et al.
The Journal of cell biology, 215(5), 719-734 (2016)
A Migheli et al.
Neuroscience letters, 261(1-2), 25-28 (1999-03-19)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss and astrogliosis. We studied the immunohistochemical expression of S-100beta, a calcium-binding protein with both neurotrophic and neurotoxic activities, in the spinal cord of patients with ALS.
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During embryonic spinal cord development, neural progenitor cells (NPCs) generate three major cell lines: neurons, oligodendrocytes, and astrocytes at precise times and locations within the spinal cord. Recent studies demonstrate early astrogenesis in animal models of spina bifida, which may
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