SAB2501101
Anti-VMAT2/SLC18A2 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-SLC18A2, Anti-SVAT, Anti-SVMT, Anti-VAT2
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC18A2(6571)
General description
Solute carrier family 18 member A2 (SLC18A2) or vesicular monoamine transporter 2 (VMAT2) is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding SLC18A2 consists of 16 exons and is localized on human chromosome 10q25.
Immunogen
Peptide with sequence C-SYPIGEDEESESD from the C Terminus of the protein sequence according to NP_003045.2.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Solute carrier family 18 member A2 (SLC18A2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. SLC18A2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Vesicular monoamine transporter, type 2 (VMAT2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas.
Freeby M
Islets (2012)
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L
Neurobiology of Aging (2013)
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.
Zai CC
Journal of Psychiatric Research (2013)
Shiliang Zhang et al.
Nature neuroscience, 18(3), 386-392 (2015-02-11)
Mesoaccumbens fibers are thought to co-release dopamine and glutamate. However, the mechanism is unclear, and co-release by mesoaccumbens fibers has not been documented. Using electron microcopy, we found that some mesoaccumbens fibers have vesicular transporters for dopamine (VMAT2) in axon
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