SAB2500781
Anti-PGC1A antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-LEM6, Anti-PPARGC1A, Anti-Peroxisome proliferator-activated receptor γ
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, canine, rat
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PPARGC1A(10891)
General description
Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.
Immunogen
Peptide with sequence C-DGLFDDSEDESDK from the internal region of the protein sequence according to NP_037393.1.
Application
Anti-PGC1A antibody produced in goat has been used in Western blotting.
Biochem/physiol Actions
Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘molecular switch′ in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes.
Soyal S
Diabetologia, 49(7), 1477-1488 (2006)
Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)
Benjamin L. Farah
Nature, 7 (2017)
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Handschin C
Genes & Development, 21(7), 770-783 (2007)
PGC-1alpha: a key regulator of energy metabolism.
Liang H and Ward WF
Advances in Physiology Education, 30(4), 145-151 (2006)
A PGC-1? isoform induced by resistance training regulates skeletal muscle hypertrophy.
Ruas JL
Cell, 151(6), 1319-1331 (2012)
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