SAB2101106
Anti-HTR2A antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-5-HT2A, Anti-5-hydroxytryptamine (serotonin) receptor 2A, Anti-HTR2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
52 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HTR2A(3356)
General description
5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2.
Immunogen
Synthetic peptide directed towards the N terminal region of human HTR2A
Biochem/physiol Actions
5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSEN
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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The role of serotonin 5-HT2A receptors in memory and cognition
Zhang G and Stackman Jr RW
Frontiers in Pharmacology, 6, 225-225 (2015)
Functional selectivity and classical concepts of quantitative pharmacology
Urban JD, et al.
Journal of Pharmacology and Experimental Therapeutics, 320(1), 1-13 (2007)
Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
Abdolmaleky HM, et al.
Schizophrenia Research, 129(2-3), 183-190 (2011)
Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment
Horstmann S, et al.
Neuropsychopharmacology, 35(3), 727-740 (2010)
Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression
Myers RL, et al.
Biological Psychiatry, 61(2), 167-173 (2007)
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