SAB1403609
Monoclonal Anti-BMP2, (C-terminal) antibody produced in mouse
clone 4B12, purified immunoglobulin, buffered aqueous solution
Synonym(s):
BMP2A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4B12, monoclonal
form
buffered aqueous solution
mol wt
antigen ~38.65 kDa
species reactivity
human
technique(s)
indirect ELISA: suitable
proximity ligation assay: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BMP2(650)
General description
Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β (TGF-β) superfamily. It is expressed in a variety of tissues such as heart, lung and dorsal aorta. The gene encoding this protein is localized on human chromosome 20p12.3.
Immunogen
BMP2 (NP_001191, 283 a.a. ~ 396 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Sequence
QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Biochem/physiol Actions
Bone morphogenetic proteins (BMPs) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP2 controls the expression of Runt-related transcription factor 2 (Runx2) and osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP2 also plays an important role in cardiac morphogenesis.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
BMP and BMP inhibitors in bone.
Rosen V
Annals of the New York Academy of Sciences (2006)
Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells Cultured in 3D Copolymer Scaffolds Enhances Bone Formation.
Sharma S
PLoS ONE (2016)
BMP2 is required for early heart development during a distinct time period.
Schlange T
Mechanisms of Development (2000)
Duplications Involving a Conserved Regulatory Element Downstream of BMP2 Are Associated with Brachydactyly Type A2
KatarinaDathe
Academic Journal of Interdisciplinary Studies (2009)
Alternative Neural Crest Cell Fates Are Instructively Promoted by TGF? Superfamily Members
Nirao MShah
Cell (1996)
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