SAB1306582
Anti-Ubiquitin antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Polyubiquitin-C, UBC, Ubiquitin
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
77039 Da
species reactivity
human
technique(s)
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UBC(7316)
General description
Ubiquitin, also known as ubiquitin C (UBC), is a globular protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein consists of 76 amino acids.
Immunogen
a synthetic peptide between 36-66 amino acids of human Ubiquitin, which is in the Ubiquitin-like 1 domain
Application
Anti-ubiquitin antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Ubiquitin plays a major role in protein degradation. Ubiquitin-mediated degradation of regulatory proteins has been implicated in the regulation of various processes, such as cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation and endocytosis. Aberrations in the ubiquitin-mediated pathways contribute to malignant transformation.
Physical form
Supplied in PBS with 0.09% (W/V) sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3.
Board PG, et al.
Genomics, 12, 639-642 (1992)
Ubiquitin recognition by the proteasome
Saeki Y, et al.
Journal of Biochemistry, 161, 113-124 (2017)
The VHL short variant involves in protein quality control
Liu Y, et al.
Gene, 589, 63-71 (2016)
Loss of heterozygosity: what is it good for?
Ryland GL, et al.
BMC Medical Genomics (2015)
Myocardin regulates BMP10 expression and is required for heart development
Huang J, et al.
The Journal of Clinical Investigation, 122, 3678-3691 (2012)
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