RAB1476
Human GAPHD ELISA
for serum, plasma and cell culture supernatants
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.82 ng/mL
standard curve range: 0.819-200 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GAPDH(2597)
Related Categories
General description
The GAPHD (glyceraldehyde-3-phosphate dehydrogenase) gene is mapped to human chromosome 12p13.31. GAPHD encodes a multifunctional protein which is a glycolytic enzyme.
This ELISA antibody pair detects human GAPHD. Other species not yet determined.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
GAPHD (glyceraldehyde-3-phosphate dehydrogenase) is associated with the progression of Huntington′s disease by increasing cytotoxicity. Gaphd is often referred to as glycolytic enzyme and catalyzes the sixth step in glycolysis. The Gaphd enzyme possess uracil-DNA glycosylase activity. The enzyme regulates transcription, posttranscriptional gene expression, intracellular membrane trafficking and apoptosis.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death.
Nakajima H, et al.
The Journal of Biological Chemistry (2017)
A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates.
Lazarev V F, et al.
Biochemical and Biophysical Research Communications, 487(3), 723-727 (2017)
Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair
Kosova A A, et al.
Biochemistry (Moscow), 82(6), 643-654 (2017)
Prediction of potential cancer-risk regions based on transcriptome data: towards a comprehensive view.
Alisoltani A, et al.
PLoS ONE, 9(5), e96320-e96320 (2014)
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