PRS3363
Anti-ST2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Interleukin 1 receptor-like 1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il1rl1(17082)
General description
ST2 (suppression of tumorigenicity) belongs to the IL-1 family of cytokines. It is also known as IL-33 (interleukin 33) and IL1RL1 (interleukin 1 receptor like 1). It is expressed in macrophages and various inflammatory cells like T helper 2 (Th2), mast cells, basophils and eosinophils. It is mapped to chromosome 2q12.
Immunogen
a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.
Application
Anti-ST2 has been used in immunohistochemistry, western blottingand immunofluorescence staining.
Biochem/physiol Actions
ST2 (suppression of tumorigenicity) participates in pathophysiology of several diseases like asthma, arthritis, obesity and atherosclerosis. It works as a mitogen in eosinophils, fibrocytes, endothelial cells. It helps in the migration of Th2 lymphocytes, fibrocytes and endothelial cells, and disturbs the incursion and metastasis of breast tumor.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3363.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Mertz KD, et al.
Oncoimmunology, 5(1) (2015)
Xiao-Hui Wang et al.
Molecular medicine reports, 16(4), 3887-3893 (2017-08-03)
Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated
Wen-Ting Hu et al.
Molecular human reproduction, 20(4), 358-372 (2013-12-18)
Interleukin (IL)-33, a newly described member of the IL-1 family, has been reported to facilitate primary tumor progression and metastatic dissemination. However, its biological function on decidual stromal cells (DSCs) remains unclear. In this study, we tested the hypothesis whether
Mamdouh A K Sedhom et al.
Gut, 62(12), 1714-1723 (2012-11-23)
Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in
ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples
Marzullo A, et al.
PLoS ONE, 11(5) (2016)
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