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P9158

Pyridoxamine dihydrochloride

BioReagent, suitable for cell culture

Synonym(s):

4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H12N2O2 · 2HCl
CAS Number:
524-36-7
Molecular Weight:
241.11
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
24899015
EC Number:
208-357-6
Beilstein/REAXYS Number:
3632748
MDL number:
MFCD00012808
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biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

assay

≥98%

form

powder

mol wt

Mw 241.11 g/mol

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

224-226 °C (dec.) (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Cc1ncc(CO)c(CN)c1O

InChI

1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H

InChI key

HNWCOANXZNKMLR-UHFFFAOYSA-N

Application

Use in mammalian cell culture as an alternative to pyridoxine or pyridoxal. Vitamin B6 is a required component of cell culture media. Historically, media have been supplemented with vitamin B6 in the aldehyde form, pyridoxal. While this is a biologically active form of vitamin B6, it is unstable in liquid media. When cells are able to utilize either pyridoxine and/or pyridoxamine, they are preferred supplement versus pyridoxal. A number of classical media are now offered with a choice between pyridoxal and pyridoxine as the vitamin A source.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
096K18481
085H08936
110K10875
110K10871
031K11206

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Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

Petia Kovatcheva-Datchary et al.
Cell reports, 26(13), 3772-3783 (2019-03-28)
The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To

Global Trade Item Number

SKUGTIN
P9158-1G04061834402534