M3184
MG 624
≥98%
Synonym(s):
N,N,N-Triethyl-2-(4-trans-stilbenoxy)ethylammonium iodide
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About This Item
Empirical Formula (Hill Notation):
C22H30INO
CAS Number:
Molecular Weight:
451.38
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98%
solubility
DMSO: ≤22 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
[I-].CC[N+](CC)(CC)CCOc1ccc(cc1)\C=C\c2ccccc2
InChI
1S/C22H30NO.HI/c1-4-23(5-2,6-3)18-19-24-22-16-14-21(15-17-22)13-12-20-10-8-7-9-11-20;/h7-17H,4-6,18-19H2,1-3H3;1H/q+1;/p-1/b13-12+;
InChI key
RDTKUZXIHMTSJO-UEIGIMKUSA-M
Gene Information
human ... CHRNA7(1139)
Biochem/physiol Actions
Nicotinic acetylcholine receptor antagonist; selectively inhibits neuronal nicotinic α-bungarotoxin sensitive receptors that contain the α7 subunit.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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C Gotti et al.
British journal of pharmacology, 124(6), 1197-1206 (1998-08-28)
1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and studied their selective effect on neuronal nicotinic acetylcholine receptor
Glenn W Vicary et al.
Respiratory research, 18(1), 115-115 (2017-06-04)
Tobacco-related chronic lung diseases are characterized by alterations in lung architecture leading to decreased lung function. Knowledge of the exact mechanisms involved in tobacco-induced tissue remodeling and inflammation remains incomplete. We hypothesize that nicotine stimulates the expression of extracellular matrix
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