M1777
N-Methyl-1-deoxynojirimycin
≥98%
Synonym(s):
1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol
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About This Item
Empirical Formula (Hill Notation):
C7H15NO4
CAS Number:
Molecular Weight:
177.20
UNSPSC Code:
51102829
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1524564
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChI key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
Gene Information
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Si(497756)
General description
Chemical structure: glucosamine
Biochem/physiol Actions
Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
K Mori et al.
Biochimica et biophysica acta, 1226(3), 300-306 (1994-07-18)
We studied the effect of the glucosidase I inhibitor, N-methyl-1-deoxynojirimycin (MdN) and the mannosidase inhibitor, 1-deoxymannojirimycin (dMM) on the biosynthesis and secretion of alpha 2-plasmin inhibitor (alpha 2-PI) and antithrombin III (ATIII) in cultures of human hepatoma (Hep-G2) cells. Incubation
M Arai et al.
Circulation, 97(13), 1290-1297 (1998-05-07)
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase of glycogen-debranching enzyme in the liver, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Because the reduction of the glycogenolytic rate may
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M1777-5MG | 04061833272800 |