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MilliporeSigma

I9385

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

whole antiserum

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i)
Citations:
5
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biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

secondary antibodies

clone

polyclonal

contains

15 mM sodium azide

technique(s)

indirect ELISA: 1:20,000

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

IgM is a pentameric immunoglobulin, with each monomer having a light and heavy chain. The two types of IgM comprise natural and adaptive.

Application

Anti-Human IgM (μ-chain specific) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.

Biochem/physiol Actions

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
IgM serves as prime antibody in providing defense. It activates complement C1q. It is regarded as a marker for identifying tumor-associated antigens. Hyper-IgM syndrome is implicated with high IgM levels accompanied by low IgA, IgG and IgE levels.

Preparation Note

treated to remove lipoproteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter



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Related Content


Evaluation of a patient with hyper-IgM syndrome
Uygungil B, et al.
The Journal of Allergy and Clinical Immunology, 129(6), 1692-1692 (2012)
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias
Czajkowsky DM and Shao Z
Proceedings of the National Academy of Sciences of the USA, 106(35), 14960-14965 (2009)
Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer
Diaz-Zaragoza M, et al.
Oncology Reports, 34(3), 1106-1114 (2015)



Global Trade Item Number

SKUGTIN
I9385-2ML04061837518119