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MilliporeSigma

H9268

Sigma-Aldrich

Hexadimethrine bromide

≥94% (titration)

Synonym(s):

1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide, Polybrene

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About This Item

CAS Number:
28728-55-4
MDL number:
MFCD00133397
UNSPSC Code:
41106502
NACRES:
NA.26

Key Documents

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Quality Level

200

assay

≥94% (titration)

storage temp.

2-8°C

SMILES string

BrCCCBr.N(CCCCCCN(C)C)(C)C

InChI

1S/C10H24N2.C3H6Br2/c1-11(2)9-7-5-6-8-10-12(3)4;4-2-1-3-5/h5-10H2,1-4H3;1-3H2

InChI key

KZKAYEGOIJEWQB-UHFFFAOYSA-N

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General description

Hexadimethrine bromide is a quaternary ammonium compound which works as a heparin antagonist. It is also involved in the transformation of low molecular weight DNA.

Application

Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.
Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP5260
MKCP0527
MKCM1623
MKCG8652
MKCL4093

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Redei GP
Encyclopedia of Genetics, Genomics, Proteomics, and Informatics (2008)
S Kawai et al.
Molecular and cellular biology, 4(6), 1172-1174 (1984-06-01)
A new procedure for DNA transfection has been developed in a system of chicken embryo fibroblast cells and cloned Rous sarcoma virus DNA by using a polycation reagent as a mediator to adsorb DNA to the cell surface and dimethyl
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.
Hershko T
The Journal of Biological Chemistry, 281, 31309-31309 (2006)
Molecular pathways regulating pro-migratory effects of Hedgehog signaling.
Hochman E et al.
The Journal of Biological Chemistry, 281, 33860-33860 (2006)
Gaetana Restivo et al.
Nature communications, 8(1), 1988-1988 (2017-12-08)
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic capacity. According to the "phenotype switching" model, the aggressive nature of melanoma cells results from their intrinsic potential to dynamically switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive
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