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MilliporeSigma

H7630

Sigma-Aldrich

Hyaluronic acid sodium salt from bovine vitreous humor

Synonym(s):

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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About This Item

Linear Formula:
(C14H21NaNO11)n
CAS Number:
9067-32-7
MDL number:
MFCD01773053
UNSPSC Code:
12352201
NACRES:
NA.77

Key Documents

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biological source

bovine (vitreous humor)

Quality Level

200

form

powder

color

white

solubility

water: ~5 g/L

storage temp.

−20°C

SMILES string

[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

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Application

Hyaluronic acid sodium salt from bovine vitreous humor has been used:
  • as a component for the generation of artificial synovial fluid
  • to investigate its role in inducing oxidative stress and interleukin 8(IL-8) production in human nasal RPMI 2650 cells
  • to test its effect on B cell proliferation
  • as a substrate in neuraminidase assay of morbilliviruses virus

Biochem/physiol Actions

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Hyaluronic acid (HA) is abundantly present in the bovine vitreous humor. It corresponds to a molecular weight of 69293.9Da and has an isoelectric pH of 5.82. Bovine HA has high levels of endotoxins and it polydisperse with DNA and RNA contaminants. The enzyme HA synthases at the plasma membrane (HASs) aids in the synthesis of circulatory HA. HA is implicated in many physiological processes including inflammation, immune regulation, adhesion, embryo development and tumor progression.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBK8637V
SLBF6293V
018K37791
018K3779
098H3785

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Evaluation of hyaluronic acid in cattle: physiological variations related to age, periparturition and in clinical cases of paratuberculosis
Jolly A, et al.
Journal of Veterinary Science and Technology, 7(4), 342-346 (2016)
Evaluation of Hyaluronan from Different Sources: Streptococcus z ooepidemicus, Rooster Comb, Bovine Vitreous, and Human Umbilical Cord
Shiedlin A, et al.
Biomacromolecules, 5(6), 2122-2127 (2004)
Effect of high, medium, and low molecular weight hyaluronan on inflammation and oxidative stress in an in vitro model of human nasal epithelial cells
Albano GD, et al.
Mediators of Inflammation, 2016 (2016)
Yi-Wen Lin et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-01)
Osteoarthritis (OA) is the most common joint disease type and is accompanied by varying degrees of functional limitation. Both hyaluronic acid (HA) joint injections and pain relievers are efficient treatments for early-stage osteoarthritis. However, for the decomposition by hyaluronidase and
Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin.
Langedijk JP, et al.
Journal of virology, 71(8), 6155-6167 (1997)
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Articles

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Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Protocols

Enzymatic Assay of Hyaluronidase (3.2.1.35)

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

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