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G2879

Glycine hydrochloride

Name: Glycine hydrochloride
Brand: SIGMA

≥99% (HPLC), NMDA receptors regulator, powder

Synonym(s):

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

H₂NCH₂CO₂H · HCl

CAS Number:

6000-43-7

Molecular Weight:

111.53

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24895108

NACRES:

NA.32

EC Number:

227-841-8

MDL number:

MFCD00012872

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Properties

Product Name

Glycine hydrochloride, ≥99% (HPLC)

Quality Level

300

assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl.NCC(O)=O

InChI

1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H

InChI key

IVLXQGJVBGMLRR-UHFFFAOYSA-N

Description

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used:

in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP)

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Biochem/physiol Actions

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

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pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

Stripping and Reprobing Western Blotting Membranes

This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

Global Trade Item Number

SKU	GTIN
G2879-1KG	04061826744826
G2879-100G	04061833629543
G2879-500G	04061833629550